Publications

  1. Rina Nakamura, Motomi Konishi, Emiri Ushijima, Ryuichirou Tanaka, Masanari Taniguchi, Aya Kojima, Miho Tokumasu, Tadashi Yamamoto, Toshifumi Akizawa: Structural analysis of the novel hydrolase-like peptide, Journal of Peptides Science, 22(52), S163, ISSN 1075-2617, 2016 (IF 1.905) 
  2. Toshifumi Akizawa, Rina Nakamura, Aya Kojima, Motomi Konishi, Masanari Taniguchi, Miho Tokumasu, Tadashi Yamamoto: Finding of the novel hydrolase-like peptide (JAL-TA9) digesting Aβ protein, Journal of Peptides Science, 22(52), S32, ISSN 1075-2617, 2016 (IF 1.905) 
  3. Masanari Taniguchi, Kazuki Matsuura, Rina Nakamura, Aya Kojima, Motomi Konishi, Toshifumi Akizawa: MMP-7 cleaves amyloid β fragment peptides and copper ion inhibits the degradation, Biometals. 30(5): 797-807, 2017 (IF 2.949)        
  4. Rina Nakamura, Aya Kojima, Masanari Taniguchi, Motomi Konishi, Miho Tokumasu, Tadashi Yamamoto, Toshifumi Akizawa: The Novel Finding of Serine Protease-Like Peptide, Peptide Science 2016, The Japanese Peptide Society 2017, pp. 17-18
  5. Yusuke Hatakawa, Rina Nakamura, Masanari Taniguchi, Motomi Konishi, Miho Tokumasu, Tadashi Yamamoto, Toshifumi Akizawa: The Synthetic Peptide Derived from BoxA Region in ANA/BTG3 Proteins is The Second Catalytide Cleaving the Amyloid-β Peptide, Peptide Science 2016, The Japanese Peptide Society 2017, pp. 123-124
  6. Yusuke Ueba, Takaaki Aratake, Ken-ichi Onodera, Youichirou Higashi, Tomoya Hamada, Takahiro Shimizu, Shogo Shimizu, Toshio Yawata, Rina Nakamura, Toshifumi Akizawa, Tetsuya Ueba, Motoaki Saito: Attenuation of zinc-enhanced inflammatory M1 phenotype of microglia by peridinin protects against short-term spatial-memory impairment following cerebral ischemia in mice, BBRC, 507, 475-483, 2018 (IF 3.575)
  7. Rina Nakamura, Yusuke Hatakawa, Motomi Konishi, Masanari Taniguchi, Toshifumi Akizawa: Structure-Activity Relationship of 5-mer Peptides Derived from JAL-TA9, Peptide Science 2017, The Japanese Peptide Society 2018, pp. 40-41
  8. Yusuke Hatakawa, Rina Nakamura, Masanari Taniguchi, Motomi Konishi and Toshifumi Akizawa: Comparison of Proteolytic Activity of 5-Mer Peptides Derived from BoxA Domain of Tob/BTG Family Proteins, Peptide Science 2017, The Japanese Peptide Society 2018, pp. 102-103
  9. Rina Nakamura, Yusuke Hatakawa, Motomi Konishi, Motoaki Saito, Toshifumi Akizawa: The Possibility of Creating a Novel Catalytide in PC, Peptide Science 2018, The Japanese Peptide Society 2019, pp. 9-10
  10. Yuko Sakaguchi, Rina Nakamura, Motomi Konishi, Masanari Taniguchi, Hidenao Toyoda, Toshifumi Akizawa: The effects of Cu2+ on conformational changes of hPrP180-192 derived from C-terminal region of prion protein, ERBT. 30 (1):1-8, 2019
  11. Yuko Sakaguchi, Rina Nakamura, Motomi Konishi, Yusuke Hatakawa, Hidenao Toyoda, Toshifumi Akizawa: Effects of Cu2+ on conformational change and aggregation of hPrP180-192 with a V180I mutation of the prion protein, BBRC, 514, 798-802, 2019 (IF 3.575)
  12. Rina Nakamura, Motomi Konishi, Masanari Taniguchi, Yusuke Hatakawa, Toshifumi Akizawa: The discovery of shorter synthetic proteolytic peptides derived from Tob1 protein, Peptides 116, 71-77, 2019 (IF 3.750)
  13. Rina Nakamura, Motomi Konishi, Yoichiro Higashi, Motoaki Saito, Toshifumi Akizawa: Comparison of the catalytic activities of 5-mer synthetic peptides derived from Box A region of Tob/BTG family proteins against the amyloid-beta fragment peptides, Integrative Molecular Medicine, 6, 1-4, 2019 (IF 2.710)
  14. Rina Nakamura, Motomi Konishi, Yusuke Hatakawa, Motoaki Saito, Toshifumi Akizawa: The Novel Catalytic Peptide, A Synthetic Nona-Peptide (JAL-TA9) Derived from Tob1 Protein, Digested the Amyloid-β Peptide, Journal of Royal Science, 1, (2) 30-35, 2019 (IF 2.963)
  15. Yusuke Hatakawa, Rina Nakamura, Motomi Konishi, Toshiyasu Sakane, Motoaki Saito, Toshifumi Akizawa: Catalytides derived from the Box A region in the ANA/BTG3 protein cleave amyloid-b fragment peptide, Helion 5 e02454, 2019 (IF 2.850)
  16. Tomoya Hamada, Takaaki Aratake, Youichirou Higashi, Yusuke Ueba, Takahiro Shimizu, Shougo Shimizu, Toshio Yawata, Tetsuya Ueba, Rina Nakamura, Toshifumi Akizawa, Mikiya Fujieda, Motoaki Saito: Zinc-aggravated M1 microglia regulate astrocytic engulfment via P2×7 receptors, J. Trace Elem. Med. Biol. 61: 126518,2020 (IF 3.849)
  17. Rina Nakamura, Motomi Konishi, Yuko Sakaguchi, Yusuke Hatakawa, Akiko Tanaka, Toshiyasu Sakane, Motoaki Saito, Toshifumi Akizawa: JAL-TA9 Inhibits Aggregation of hPrP180-192 through the Cleavage Reaction, J Pharm Pharmacol Res 4 (2): 23-32, 2020 (IF 3.765)
  18. Yusuke Hatakawa, Rina Nakamura, Motomi Konishi, Toshiyasu Sanane, Akiko Tanaka, Akira Matsuda, Motoaki Saito, Toshifumi Akizawa: Amyloid-beta cleavage by ANA-TA9, a synthetic peptide from the ANA/BTG3 Box A region. Alzheimers Dement (N Y), 31;7(1): e12146, 2021 (IF 7.099)
  19. Yusuke Hatakawa, Akiko Tanaka, Tomoya Furubayashi, Rina Nakamura, Motomi Konishi, Toshifumi Akizawa, Toshiyasu Sanane: Direct Delivery of ANA-TA9, a Peptide Capable of Aβ Hydrolysis, to the Brain by Intranasal Administration. Pharmaceutics, 13, 10,1673 (1-13), 2021 (IF 6.072)
  20. Nakamura, Rina, Toshifumi Akizawa, and Motomi Konishi: Structure – Activity Relationship of 5-Mer Catalytides, GSGYR and RYGSG. Biomolecules 2022, 12, 1766 (IF 6.064)
  21. Nakamura, R., Konishi, M., Higashi, Y. et al. Five-mer peptides prevent short-term spatial memory deficits in Aβ25-35-induced Alzheimer’s model mouse by suppressing Aβ25-35 aggregation and resolving its aggregate form. Alz Res Therapy 15, 83, 2023 (IF 9.037)

International Conferences


1. Nakamura R, Konishi M, Ushijima E, Tanaka R, Taniguchi M, Kojima A, Tokumasu M, Yamamoto T, Akizawa T: STRACTURAL ANALYSIS OF THE NOVEL HYDROLASE-LIKE PEPTIDE, 34th European Peptide Symposium, Germany-Leipzig, 2016

2.Akizawa T, Nakamura R, Kojima A, Konishi M, Taniguchi M, Tokumasu M, Yamamoto T: FINDING OF THE NOVEL HYDROLASE-LIKE PEPTIDE (JAL-TA9) DIGESTING Aβ PROTEIN, 34th European Peptide Symposium, Germany-Leipzig, 2016

3.Nakamura R, Taniguchi M, Konishi M, Ushijima E, Tanaka R, Kojima A, Tokumasu M, Yamamoto T, Akizawa T: Chemical and Physical Properties of the Novel Serine Protease-Like Peptide Digesting Amyloid-Beta Protein, 14th Asia-Pacific Federation for Clinical Biochemistry and Laboratory Medicine Congress, Taipei, 2016

4.Akizawa T, Nakamura R, Kojima A, Konishi M, Taniguchi M, Tokumasu M, Yamamoto T: Discover of the Novel Serine Protease-like Peptide digesting Amyloid-Beta Protein, 14th Asia-Pacific Federation for Clinical Biochemistry and Laboratory Medicine Congress, Taipei, 2016

5.Hatakawa Y, Nakamura R, Taniguchi M, Konishi M, Yamamoto T, Akizawa T: The shorter synthetic peptides derived from Box A region in ANA/BTG3 protein are the novel enzyme peptides and cleave the amyloid-beta peptide, 10th GENERAL MEETING OF THE INTERNATIONAL PROTEOLYSIS SOCIETY, Banff, CANADA, 2017