{"id":223,"date":"2022-07-26T03:10:49","date_gmt":"2022-07-26T03:10:49","guid":{"rendered":"https:\/\/o-force.info\/?page_id=223"},"modified":"2025-09-09T00:53:53","modified_gmt":"2025-09-09T00:53:53","slug":"publication-1","status":"publish","type":"page","link":"https:\/\/o-force.info\/index.php\/institute\/publication-1\/","title":{"rendered":"\u696d\u7e3e"},"content":{"rendered":"\n
<\/span>
\n

\u5b66\u8853\u8ad6\u6587<\/p>\n\n\n\n

\uff3b\u539f\u8457\uff0c\u6b27\u6587\uff3d<\/p>\n\n\n\n

    \n
  1. Rina Nakamura, Motomi Konishi, Emiri Ushijima, Ryuichirou Tanaka, Masanari Taniguchi, Aya Kojima, Miho Tokumasu, Tadashi Yamamoto, Toshifumi Akizawa: Structural analysis of the novel hydrolase-like peptide, Journal of Peptides Science, 22(52), S163, ISSN 1075-2617, 2016 (IF 1.905)\u3000<\/li>\n\n\n\n
  2. Toshifumi Akizawa, Rina Nakamura, Aya Kojima, Motomi Konishi, Masanari Taniguchi, Miho Tokumasu, Tadashi Yamamoto: Finding of the novel hydrolase-like peptide (JAL-TA9) digesting A\u03b2 protein, Journal of Peptides Science, 22(52), S32, ISSN 1075-2617, 2016 (IF 1.905)\u3000<\/li>\n\n\n\n
  3. Masanari Taniguchi, Kazuki Matsuura, Rina Nakamura, Aya Kojima, Motomi Konishi, Toshifumi Akizawa: MMP-7 cleaves amyloid \u03b2 fragment peptides and copper ion inhibits the degradation, Biometals. 30(5): 797-807, 2017 (IF 2.949)        <\/li>\n\n\n\n
  4. Rina Nakamura, Aya Kojima, Masanari Taniguchi, Motomi Konishi, Miho Tokumasu, Tadashi Yamamoto, Toshifumi Akizawa: The Novel Finding of Serine Protease-Like Peptide, Peptide Science 2016, The Japanese Peptide Society 2017, pp. 17-18<\/li>\n\n\n\n
  5. Yusuke Hatakawa, Rina Nakamura, Masanari Taniguchi, Motomi Konishi, Miho Tokumasu, Tadashi Yamamoto, Toshifumi Akizawa: The Synthetic Peptide Derived from BoxA Region in ANA\/BTG3 Proteins is The Second Catalytide Cleaving the Amyloid-\u03b2 Peptide, Peptide Science 2016, The Japanese Peptide Society 2017, pp. 123-124<\/li>\n\n\n\n
  6. Yusuke Ueba, Takaaki Aratake, Ken-ichi Onodera, Youichirou Higashi, Tomoya Hamada, Takahiro Shimizu, Shogo Shimizu, Toshio Yawata, Rina Nakamura, Toshifumi Akizawa, Tetsuya Ueba, Motoaki Saito: Attenuation of zinc-enhanced inflammatory M1 phenotype of microglia by peridinin protects against short-term spatial-memory impairment following cerebral ischemia in mice, BBRC, 507, 475-483, 2018 (IF 3.575)<\/li>\n\n\n\n
  7. Rina Nakamura, Yusuke Hatakawa, Motomi Konishi, Masanari Taniguchi, Toshifumi Akizawa: Structure-Activity Relationship of 5-mer Peptides Derived from JAL-TA9, Peptide Science 2017, The Japanese Peptide Society 2018, pp. 40-41<\/li>\n\n\n\n
  8. Yusuke Hatakawa, Rina Nakamura, Masanari Taniguchi, Motomi Konishi and Toshifumi Akizawa: Comparison of Proteolytic Activity of 5-Mer Peptides Derived from BoxA Domain of Tob\/BTG Family Proteins, Peptide Science 2017, The Japanese Peptide Society 2018, pp. 102-103<\/li>\n\n\n\n
  9. Rina Nakamura, Yusuke Hatakawa, Motomi Konishi, Motoaki Saito, Toshifumi Akizawa: The Possibility of Creating a Novel Catalytide in PC, Peptide Science 2018, The Japanese Peptide Society 2019, pp. 9-10<\/li>\n\n\n\n
  10. Yuko Sakaguchi, Rina Nakamura, Motomi Konishi, Masanari Taniguchi, Hidenao Toyoda, Toshifumi Akizawa: The effects of Cu2+<\/sup> on conformational changes of hPrP180-192 derived from C-terminal region of prion protein, ERBT. 30 (1):1-8, 2019<\/li>\n\n\n\n
  11. Yuko Sakaguchi, Rina Nakamura, Motomi Konishi, Yusuke Hatakawa, Hidenao Toyoda, Toshifumi Akizawa: Effects of Cu2+<\/sup> on conformational change and aggregation of hPrP180-192 with a V180I mutation of the prion protein, BBRC, 514, 798-802, 2019 (IF 3.575)<\/li>\n\n\n\n
  12. Rina Nakamura, Motomi Konishi, Masanari Taniguchi, Yusuke Hatakawa, Toshifumi Akizawa: The discovery of shorter synthetic proteolytic peptides derived from Tob1 protein, Peptides 116, 71-77, 2019 (IF 3.750)<\/a><\/li>\n\n\n\n
  13. Rina Nakamura, Motomi Konishi, Yoichiro Higashi, Motoaki Saito, Toshifumi Akizawa: Comparison of the catalytic activities of 5-mer synthetic peptides derived from Box A region of Tob\/BTG family proteins against the amyloid-beta fragment peptides, Integrative Molecular Medicine, 6, 1-4, 2019 (IF 2.710)<\/a><\/li>\n\n\n\n
  14. Rina Nakamura, Motomi Konishi, Yusuke Hatakawa, Motoaki Saito, Toshifumi Akizawa: The Novel Catalytic Peptide, A Synthetic Nona-Peptide (JAL-TA9) Derived from Tob1 Protein, Digested the Amyloid-\u03b2 Peptide, Journal of Royal Science, 1, (2) 30-35, 2019 (IF 2.963)<\/a><\/li>\n\n\n\n
  15. Yusuke Hatakawa, Rina Nakamura, Motomi Konishi, Toshiyasu Sakane, Motoaki Saito, Toshifumi Akizawa: Catalytides derived from the Box A region in the ANA\/BTG3 protein cleave amyloid-b fragment peptide, Helion 5 e02454, 2019 (IF 2.850)<\/a><\/li>\n\n\n\n
  16. Tomoya Hamada, Takaaki Aratake, Youichirou Higashi, Yusuke Ueba, Takahiro Shimizu, Shougo Shimizu, Toshio Yawata, Tetsuya Ueba, Rina Nakamura, Toshifumi Akizawa, Mikiya Fujieda, Motoaki Saito: Zinc-aggravated M1 microglia regulate astrocytic engulfment via P2\u00d77 receptors, J. Trace Elem. Med. Biol. 61: 126518,2020 (IF 3.849)<\/a><\/li>\n\n\n\n
  17. Rina Nakamura, Motomi Konishi, Yuko Sakaguchi, Yusuke Hatakawa, Akiko Tanaka, Toshiyasu Sakane, Motoaki Saito, Toshifumi Akizawa: JAL-TA9 Inhibits Aggregation of hPrP180-192 through the Cleavage Reaction, J Pharm Pharmacol Res 4 (2): 23-32, 2020 (IF 3.765)<\/a><\/li>\n\n\n\n
  18. Yusuke Hatakawa, Rina Nakamura, Motomi Konishi, Toshiyasu Sanane, Akiko Tanaka, Akira Matsuda, Motoaki Saito, Toshifumi Akizawa: Amyloid-beta cleavage by ANA-TA9, a synthetic peptide from the ANA\/BTG3 Box A region. Alzheimers Dement (N Y), 31;7(1): e12146, 2021 (IF 7.099)<\/a><\/li>\n\n\n\n
  19. Yusuke Hatakawa, Akiko Tanaka, Tomoya Furubayashi, Rina Nakamura, Motomi Konishi, Toshifumi Akizawa, Toshiyasu Sanane: Direct Delivery of ANA-TA9, a Peptide Capable of A\u03b2 Hydrolysis, to the Brain by Intranasal Administration. Pharmaceutics, 13, 10,1673 (1-13), 2021 (IF 6.072)<\/a><\/li>\n\n\n\n
  20. Nakamura, Rina, Toshifumi Akizawa, and Motomi Konishi: Structure \u2013 Activity Relationship of 5-Mer Catalytides, GSGYR and RYGSG. Biomolecules, 12, 1766, 2022<\/a> (IF 6.064)<\/a><\/li>\n\n\n\n
  21. Nakamura, R., Konishi, M., Higashi, Y.\u00a0et al.<\/em>\u00a0Five-mer peptides prevent short-term spatial memory deficits in A\u03b225-35-induced Alzheimer\u2019s model mouse by suppressing A\u03b225-35 aggregation and resolving its aggregate form.\u00a0Alz Res Therapy\u00a015, 83, 2023 (IF 9.037)<\/a><\/li>\n\n\n\n
  22. <\/a>Hatakawa, Y.; Nakamura, R.; Akizawa, T.; Konishi, M.; Matsuda, A.; Oe, T.; Saito, M.; Ito, F. SKGQA, a Peptide Derived from the ANA\/BTG3 Protein, Cleaves Amyloid-\u03b2 with Proteolytic Activity.\u00a0Biomolecules\u00a0,\u00a014, 586. 2024\u00a0<\/a> https:\/\/doi.org\/10.3390\/biom14050586<\/a> (IF 4.8)<\/li>\n\n\n\n
  23. Nakamura, R.; Matsuda, A.; Higashi, Y.; Hayashi, Y.; Konishi, M.; Saito, M.; Akizawa, T. An 11-mer Synthetic Peptide Suppressing Aggregation of A\u03b225-35 and Resolving Its Aggregated Form Improves Test Performance in an A\u03b225-35-Induced Alzheimer\u2019s Mouse Model.\u00a0Biomolecules,\u00a0\u00a014, 1234. 2024<\/a> https:\/\/doi.org\/10.3390\/biom14101234 (IF 4.8)<\/a><\/li>\n\n\n\n
  24. Rina Nakamura, Momoka Okada, Asuka Takahashi, Yoshihiro Hayashi, Motomi Konishi, Fumiaki Ito, Ichiro Murakami, Motoaki Saito, Toshifumi Akazawa, A synthetic nonapeptide, JAL-TA9, inhibits neuronal cytotoxicity caused by A\u03b225\u201335 aggregation with proteolytic activity. Neurobiology of Aging, 156, 123-132. 2025<\/a><\/li>\n<\/ol>\n<\/div><\/div>\n\n\n\n
    <\/span>
    \n

    \u5b66\u4f1a\u767a\u8868<\/p>\n\n\n\n

    \uff3b\u56fd\u969b\u5b66\u4f1a\uff3d
    1. Nakamura R, Konishi M, Ushijima E, Tanaka R, Taniguchi M, Kojima A, Tokumasu M, Yamamoto T, Akizawa T: STRACTURAL ANALYSIS OF THE NOVEL HYDROLASE-LIKE PEPTIDE, 34th European Peptide Symposium, Germany-Leipzig, 2016<\/p>\n\n\n\n

    2.Akizawa T, Nakamura R, Kojima A, Konishi M, Taniguchi M, Tokumasu M, Yamamoto T: FINDING OF THE NOVEL HYDROLASE-LIKE PEPTIDE (JAL-TA9) DIGESTING A\u03b2 PROTEIN, 34th European Peptide Symposium, Germany-Leipzig, 2016<\/p>\n\n\n\n

    3.Nakamura R, Taniguchi M, Konishi M, Ushijima E, Tanaka R, Kojima A, Tokumasu M, Yamamoto T, Akizawa T: Chemical and Physical Properties of the Novel Serine Protease-Like Peptide Digesting Amyloid-Beta Protein, 14th Asia-Pacific Federation for Clinical Biochemistry and Laboratory Medicine Congress, Taipei, 2016<\/p>\n\n\n\n

    4.Akizawa T, Nakamura R, Kojima A, Konishi M, Taniguchi M, Tokumasu M, Yamamoto T: Discover of the Novel Serine Protease-like Peptide digesting Amyloid-Beta Protein, 14th Asia-Pacific Federation for Clinical Biochemistry and Laboratory Medicine Congress, Taipei, 2016<\/p>\n\n\n\n

    5.Hatakawa Y, Nakamura R, Taniguchi M, Konishi M, Yamamoto T, Akizawa T: The shorter synthetic peptides derived from Box A region in ANA\/BTG3 protein are the novel enzyme peptides and cleave the amyloid-beta peptide, 10th GENERAL MEETING OF THE INTERNATIONAL PROTEOLYSIS SOCIETY, Banff, CANADA, 2017<\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n\n\n\n

    <\/p>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":59,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"vkexunit_cta_each_option":"","footnotes":""},"class_list":["post-223","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/o-force.info\/index.php\/wp-json\/wp\/v2\/pages\/223","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/o-force.info\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/o-force.info\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/o-force.info\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/o-force.info\/index.php\/wp-json\/wp\/v2\/comments?post=223"}],"version-history":[{"count":52,"href":"https:\/\/o-force.info\/index.php\/wp-json\/wp\/v2\/pages\/223\/revisions"}],"predecessor-version":[{"id":2125,"href":"https:\/\/o-force.info\/index.php\/wp-json\/wp\/v2\/pages\/223\/revisions\/2125"}],"up":[{"embeddable":true,"href":"https:\/\/o-force.info\/index.php\/wp-json\/wp\/v2\/pages\/59"}],"wp:attachment":[{"href":"https:\/\/o-force.info\/index.php\/wp-json\/wp\/v2\/media?parent=223"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}