{"id":1640,"date":"2024-11-09T08:48:01","date_gmt":"2024-11-09T08:48:01","guid":{"rendered":"https:\/\/o-force.info\/?page_id=1640"},"modified":"2024-12-30T08:34:21","modified_gmt":"2024-12-30T08:34:21","slug":"ys-1116","status":"publish","type":"page","link":"https:\/\/o-force.info\/index.php\/en\/ys-1116\/","title":{"rendered":"10\/2, 2024 Discovery of small peptides (YS-RD11, YS-RE16) effective for Alzheimer's disease treatment"},"content":{"rendered":"\n<p class=\"has-large-font-size wp-block-paragraph\"><a href=\"https:\/\/www.mdpi.com\/2218-273X\/14\/10\/1234\">Nakamura, R.; Matsuda, A.; Higashi, Y.; Hayashi, Y.; Konishi, M.; Saito, M.; Akizawa, T. An 11-mer Synthetic Peptide Suppressing Aggregation of A\u03b225-35 and Resolving Its Aggregated Form Improves Test Performance in an A\u03b225-35-Induced Alzheimer\u2019s Mouse Model.&nbsp;<em>Biomolecules<\/em>&nbsp;<strong>2024<\/strong>,&nbsp;<em>14<\/em>, 1234. https:\/\/doi.org\/10.3390\/biom14101234 (IF 4.8)<\/a><\/p>\n\n\n\n<p class=\"has-white-background-color has-background has-large-font-size wp-block-paragraph\">Small peptides (YS-RD11 and YS-RE16) not only inhibited amyloid-\u03b2 (A\u03b2) aggregation but also promoted dissociation of pre-aggregated A\u03b2. Furthermore, intranasal administration of these peptides to AD model mice improved amyloid-\u03b2-induced short-term spatial memory impairment.<br>These results indicate that the peptide prevents memory impairment by inhibiting the accumulation of A\u03b2 aggregates. Peptides are expected to be an effective therapeutic agent not only for early-stage AD but also for late-stage AD.<\/p>\n\n\n\n<p class=\"has-cyan-bluish-gray-background-color has-background has-large-font-size wp-block-paragraph\"><a href=\"https:\/\/drive.google.com\/file\/d\/1oXOdRKRarUO4laYf9qIfUliVYMKbnjuL\/view?usp=drive_link\" title=\"\">An audio abstract was created by Google NotebookLM (17 min length).<\/a><\/p>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color has-large-font-size wp-elements-79cda51b1841c23ff9d1dc68a242db48 wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nakamura, R.; Matsuda, A.; Higashi, Y.; Hayashi, Y.; Konishi, M.; Saito, M.; Akizawa, T. An 11-mer Synthetic P [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"sns_share_botton_hide":"","vkExUnit_sns_title":"","_vk_print_noindex":"","sitemap_hide":"","vkExUnit_sitemap":"","_veu_custom_css":"","veu_display_promotion_alert":"common","_exclude_from_list_pages":"","vkexunit_cta_each_option":"","vkExUnit_childPageIndex":"","vkExUnit_pageList_ancestor":"","vkExUnit_contact_enable":"","footnotes":""},"class_list":["post-1640","page","type-page","status-publish","hentry"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.0.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"Nakamura, R.; Matsuda, A.; Higashi, Y.; Hayashi, Y.; Ko\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/o-force.info\/index.php\/en\/ys-1116\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 5.0.0.1\" \/>\n\t\t<meta property=\"og:locale\" content=\"ja_JP\" \/>\n\t\t<meta property=\"og:site_name\" content=\"O-Force Co., Ltd - \u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u6cbb\u7642\u85ac\u306e\u958b\u767a\u3092\u76ee\u6307\u3059\u4f1a\u793e\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"10\/2, 2024 Discovery of small peptides (YS-RD11, YS-RE16) effective for Alzheimer&#039;s disease treatment - O-Force Co., Ltd\" \/>\n\t\t<meta property=\"og:description\" content=\"Nakamura, R.; 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