{"id":1640,"date":"2024-11-09T08:48:01","date_gmt":"2024-11-09T08:48:01","guid":{"rendered":"https:\/\/o-force.info\/?page_id=1640"},"modified":"2024-12-30T08:34:21","modified_gmt":"2024-12-30T08:34:21","slug":"ys-1116","status":"publish","type":"page","link":"https:\/\/o-force.info\/index.php\/en\/ys-1116\/","title":{"rendered":"10\/2, 2024 Discovery of small peptides (YS-RD11, YS-RE16) effective for Alzheimer's disease treatment"},"content":{"rendered":"\n<p class=\"has-large-font-size\"><a href=\"https:\/\/www.mdpi.com\/2218-273X\/14\/10\/1234\">Nakamura, R.; Matsuda, A.; Higashi, Y.; Hayashi, Y.; Konishi, M.; Saito, M.; Akizawa, T. An 11-mer Synthetic Peptide Suppressing Aggregation of A\u03b225-35 and Resolving Its Aggregated Form Improves Test Performance in an A\u03b225-35-Induced Alzheimer\u2019s Mouse Model.&nbsp;<em>Biomolecules<\/em>&nbsp;<strong>2024<\/strong>,&nbsp;<em>14<\/em>, 1234. https:\/\/doi.org\/10.3390\/biom14101234 (IF 4.8)<\/a><\/p>\n\n\n\n<p class=\"has-white-background-color has-background has-large-font-size\">Small peptides (YS-RD11 and YS-RE16) not only inhibited amyloid-\u03b2 (A\u03b2) aggregation but also promoted dissociation of pre-aggregated A\u03b2. Furthermore, intranasal administration of these peptides to AD model mice improved amyloid-\u03b2-induced short-term spatial memory impairment.<br>These results indicate that the peptide prevents memory impairment by inhibiting the accumulation of A\u03b2 aggregates. Peptides are expected to be an effective therapeutic agent not only for early-stage AD but also for late-stage AD.<\/p>\n\n\n\n<p class=\"has-cyan-bluish-gray-background-color has-background has-large-font-size\"><a href=\"https:\/\/drive.google.com\/file\/d\/1oXOdRKRarUO4laYf9qIfUliVYMKbnjuL\/view?usp=drive_link\" title=\"\">An audio abstract was created by Google NotebookLM (17 min length).<\/a><\/p>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color has-large-font-size wp-elements-79cda51b1841c23ff9d1dc68a242db48\"><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nakamura, R.; Matsuda, A.; Higashi, Y.; Hayashi, Y.; Konishi, M.; Saito, M.; Akizawa, T. An 11-mer Synthetic P [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"vkexunit_cta_each_option":"","footnotes":""},"class_list":["post-1640","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/o-force.info\/index.php\/wp-json\/wp\/v2\/pages\/1640","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/o-force.info\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/o-force.info\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/o-force.info\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/o-force.info\/index.php\/wp-json\/wp\/v2\/comments?post=1640"}],"version-history":[{"count":5,"href":"https:\/\/o-force.info\/index.php\/wp-json\/wp\/v2\/pages\/1640\/revisions"}],"predecessor-version":[{"id":1876,"href":"https:\/\/o-force.info\/index.php\/wp-json\/wp\/v2\/pages\/1640\/revisions\/1876"}],"wp:attachment":[{"href":"https:\/\/o-force.info\/index.php\/wp-json\/wp\/v2\/media?parent=1640"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}