Nakamura, R.; Matsuda, A.; Higashi, Y.; Hayashi, Y.; Konishi, M.; Saito, M.; Akizawa, T. An 11-mer Synthetic Peptide Suppressing Aggregation of Aβ25-35 and Resolving Its Aggregated Form Improves Test Performance in an Aβ25-35-Induced Alzheimer’s Mouse Model. Biomolecules 2024, 14, 1234. https://doi.org/10.3390/biom14101234 (IF 4.8)

Small peptides (YS-RD11 and YS-RE16) not only inhibited amyloid-β (Aβ) aggregation but also promoted dissociation of pre-aggregated Aβ. Furthermore, intranasal administration of these peptides to AD model mice improved amyloid-β-induced short-term spatial memory impairment.
These results indicate that the peptide prevents memory impairment by inhibiting the accumulation of Aβ aggregates. Peptides are expected to be an effective therapeutic agent not only for early-stage AD but also for late-stage AD.